SubtiBank SubtiBank
Version comparison:

2019-06-06 12:19:552025-04-07 09:19:24

locus

BSU01740

BSU_01740

outlinks

bsu

BSU01740

BSU_01740

The protein

Protein family

anti-sigma-W factor family (according to Swiss-Prot)

zinc-associated anti-sigma factor (ZAS) superfamily (with [[protein|YlaD]], according to UniProt)

anti-sigma-W factor family (single member, according to UniProt)

The protein

[SW|Localization]

membrane (according to Swiss-Prot)

cell membrane (according to UniProt)

The protein

Paralogous protein(s)

[[this]]

The protein

[SW|Domains]

The cytoplasmic domain is able to inactivate SigW and the extracellular and transmembrane domains are crucial for sensing and transducing the signal that triggers SigW activation (PubMed:15130127). The N-terminus binds the zinc ion and is followed by a long helix (about residues 40-80) that fits into a hydrophobic surface groove on SigW, probably blocking its ability to interact with the -10 and -35 promoter elements (PubMed:28319136).